Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/238553608?client_source=feed&format=rss
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Tuesday, July 31, 2012
Vaccine research shows vigilance needed against evolution of more-virulent malaria
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Public release date: 31-Jul-2012[ | E-mail |
Share ] Contact: Barbara K. Kennedy
sciencew@psu.edu
814-863-4682
Penn State
Malaria parasites evolving in vaccinated laboratory mice become more virulent, according to research at Penn State University. The mice were injected with a critical component of several candidate human malaria vaccines that now are being evaluated in clinical trials. "Our research shows immunization with this particular type of malaria vaccine can create ecological conditions that favor the evolution of parasites that cause more severe disease in unvaccinated mice," said Andrew Read, Alumni Professor of Biological Sciences at Penn State.
"We are a long way from being able to assess the likelihood of this process occurring in humans, but our research suggests the need for vigilance. It is possible that more-virulent strains of malaria might evolve if a malaria vaccine goes into widespread use," Read said. The research, which will be published in the 31 July 2012 issue of the scientific journal PLoS Biology, showed that more-virulent malaria parasites evolved in response to vaccination, but the exact mechanism is still a mystery. It was not due to changes in the part of the parasite targeted by the vaccine.
No malaria vaccine ever has been approved for widespread use. "Effective malaria vaccines are notoriously difficult to develop because the malaria parasite is very complex. Hundreds of different malaria strains exist simultaneously within any local region where the disease is prevalent," Read said. Most vaccine developers use only small sections of the malaria parasite to produce an antigen molecule that then becomes a key ingredient in a highly purified malaria vaccine. Read's lab tested the antigen AMA-1, a component of several such vaccines now in various stages of clinical trials.
"Our laboratory experiments followed clues from theoretical studies and earlier experiments that suggested that some malaria vaccines could favor the evolution of more-virulent malaria parasites," Read said. If candidate vaccines do not completely eliminate all the malaria parasites, the parasites that remain have opportunities to evolve. A mosquito then could transfer the evolved parasite from the vaccinated person into a new host -- a process called leaking. "Leaky vaccines create a situation that further fosters parasite evolution," Read said.
The Penn State study found that parasites causing worse malaria symptoms in unvaccinated mice evolved after "leaking" consecutively through as few as 10 vaccinated mice. "The parasites that are able to survive in the immunized hosts must be stronger after having survived exposure to the vaccine," Read said. "The vaccine-induced immunity apparently removed the less virulent malaria parasites, but left the more virulent ones."
The AMA-1 antigen used in the Penn State study triggers the body to make anti-malaria antibodies. These antibodies recognize the AMA-1 antigen on the parasites and disable the malaria infection. The shape of the antigen ensures that the antibodies can bind securely with the malaria parasite -- like pieces in a jigsaw puzzle -- an important step in producing immunity. Scientists already knew that vaccines become obsolete when evolutionary mutations change the parasite's antigen structure in such a way that the antibody is not able to lock onto the targeted part of the parasite. But the Penn State study showed the malaria parasite evolved within the vaccinated mice even without any detectable changes in the antibody target on the parasite.
"We were surprised to find that more-virulent strains of malaria evolved even while the gene encoding the key antigen remained unchanged," said Victoria Barclay, the postdoctoral scholar in Read's lab who conducted the laboratory experiments and who is the corresponding author of the PLoS Biology paper. "We did not detect any changes in the gene sequence." The researchers conclude that evolution must have taken place somewhere in the parasite's genome. Read's lab now is hunting for the exact locations on the parasite's DNA where the mutations occurred.
"Generalizing from animal models is notoriously difficult in malaria," Read said, so the scientists do not yet know if this newly recognized type of evolution could happen in human malaria or with other rapidly evolving diseases, such as the viruses that cause AIDS or cervical cancer. "What we do know is that in Victoria Barclay's experiments in our lab at Penn State; with our parasites, our mice, and with this particular antigen; the malaria parasites that evolved through vaccinated hosts become more virulent," he said.
"Vaccines are one of the most fantastically cost-effective health gains we've ever had, so there is no question that we should proceed on all fronts to develop a safe and effective vaccine against malaria," Read said. "At the same time, our research is revealing new reasons to proceed with vigilant caution." Read suggests that vaccine researchers conducting clinical trials should not only be carefully monitoring for parasite evolution at the vaccine target, but they also should watch for mutations throughout the parasite's entire genome. "This sort of monitoring also should go on once a new vaccine goes into widespread use," he said. "It appears that in a world with leaky vaccines, virulent pathogen strains can evolve. Different vaccines or other transmission-blocking measures might be needed to stop the spread of any evolved parasites," Read said.
###
This research received financial support from Penn State University.
[ Barbara K. Kennedy ]
CONTACTS
Andrew Read: a.read@psu.edu, 814-321-5004 (cell)
Barbara Kennedy (PIO): science@psu.edu, 814-863-4682
IMAGES
High-resolution images are online at http://science.psu.edu/news-and-events/2012-news/Read7-2012
CAPTIONS (same for both images)
The image shows red blood cells, some of which are infected with ring-stage malaria parasites. Parasites invade, replicate and rupture from red blood cells multiple times during an infection.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 31-Jul-2012[ | E-mail |
Share ] Contact: Barbara K. Kennedy
sciencew@psu.edu
814-863-4682
Penn State
Malaria parasites evolving in vaccinated laboratory mice become more virulent, according to research at Penn State University. The mice were injected with a critical component of several candidate human malaria vaccines that now are being evaluated in clinical trials. "Our research shows immunization with this particular type of malaria vaccine can create ecological conditions that favor the evolution of parasites that cause more severe disease in unvaccinated mice," said Andrew Read, Alumni Professor of Biological Sciences at Penn State.
"We are a long way from being able to assess the likelihood of this process occurring in humans, but our research suggests the need for vigilance. It is possible that more-virulent strains of malaria might evolve if a malaria vaccine goes into widespread use," Read said. The research, which will be published in the 31 July 2012 issue of the scientific journal PLoS Biology, showed that more-virulent malaria parasites evolved in response to vaccination, but the exact mechanism is still a mystery. It was not due to changes in the part of the parasite targeted by the vaccine.
No malaria vaccine ever has been approved for widespread use. "Effective malaria vaccines are notoriously difficult to develop because the malaria parasite is very complex. Hundreds of different malaria strains exist simultaneously within any local region where the disease is prevalent," Read said. Most vaccine developers use only small sections of the malaria parasite to produce an antigen molecule that then becomes a key ingredient in a highly purified malaria vaccine. Read's lab tested the antigen AMA-1, a component of several such vaccines now in various stages of clinical trials.
"Our laboratory experiments followed clues from theoretical studies and earlier experiments that suggested that some malaria vaccines could favor the evolution of more-virulent malaria parasites," Read said. If candidate vaccines do not completely eliminate all the malaria parasites, the parasites that remain have opportunities to evolve. A mosquito then could transfer the evolved parasite from the vaccinated person into a new host -- a process called leaking. "Leaky vaccines create a situation that further fosters parasite evolution," Read said.
The Penn State study found that parasites causing worse malaria symptoms in unvaccinated mice evolved after "leaking" consecutively through as few as 10 vaccinated mice. "The parasites that are able to survive in the immunized hosts must be stronger after having survived exposure to the vaccine," Read said. "The vaccine-induced immunity apparently removed the less virulent malaria parasites, but left the more virulent ones."
The AMA-1 antigen used in the Penn State study triggers the body to make anti-malaria antibodies. These antibodies recognize the AMA-1 antigen on the parasites and disable the malaria infection. The shape of the antigen ensures that the antibodies can bind securely with the malaria parasite -- like pieces in a jigsaw puzzle -- an important step in producing immunity. Scientists already knew that vaccines become obsolete when evolutionary mutations change the parasite's antigen structure in such a way that the antibody is not able to lock onto the targeted part of the parasite. But the Penn State study showed the malaria parasite evolved within the vaccinated mice even without any detectable changes in the antibody target on the parasite.
"We were surprised to find that more-virulent strains of malaria evolved even while the gene encoding the key antigen remained unchanged," said Victoria Barclay, the postdoctoral scholar in Read's lab who conducted the laboratory experiments and who is the corresponding author of the PLoS Biology paper. "We did not detect any changes in the gene sequence." The researchers conclude that evolution must have taken place somewhere in the parasite's genome. Read's lab now is hunting for the exact locations on the parasite's DNA where the mutations occurred.
"Generalizing from animal models is notoriously difficult in malaria," Read said, so the scientists do not yet know if this newly recognized type of evolution could happen in human malaria or with other rapidly evolving diseases, such as the viruses that cause AIDS or cervical cancer. "What we do know is that in Victoria Barclay's experiments in our lab at Penn State; with our parasites, our mice, and with this particular antigen; the malaria parasites that evolved through vaccinated hosts become more virulent," he said.
"Vaccines are one of the most fantastically cost-effective health gains we've ever had, so there is no question that we should proceed on all fronts to develop a safe and effective vaccine against malaria," Read said. "At the same time, our research is revealing new reasons to proceed with vigilant caution." Read suggests that vaccine researchers conducting clinical trials should not only be carefully monitoring for parasite evolution at the vaccine target, but they also should watch for mutations throughout the parasite's entire genome. "This sort of monitoring also should go on once a new vaccine goes into widespread use," he said. "It appears that in a world with leaky vaccines, virulent pathogen strains can evolve. Different vaccines or other transmission-blocking measures might be needed to stop the spread of any evolved parasites," Read said.
###
This research received financial support from Penn State University.
[ Barbara K. Kennedy ]
CONTACTS
Andrew Read: a.read@psu.edu, 814-321-5004 (cell)
Barbara Kennedy (PIO): science@psu.edu, 814-863-4682
IMAGES
High-resolution images are online at http://science.psu.edu/news-and-events/2012-news/Read7-2012
CAPTIONS (same for both images)
The image shows red blood cells, some of which are infected with ring-stage malaria parasites. Parasites invade, replicate and rupture from red blood cells multiple times during an infection.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-07/ps-vrs072412.php
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HDI Announces New Congressional Advisory ... - Goodyear ATV
Humpty Dumpty Institute (HDI) was established in 1998 by a small group of business entrepreneurs. The ideas was to create a non-profit that would tackle a few tough international problems. ?One of HDI?s core interest involves the key relationship between the United State and the United Nations. Over the years, HDI has seen success, but still has a lot of work to do. HDI is always looking for partners who can help turn good ideas into effective programs. HDI has earned a reputation for strengthening ties between the U.S. Congress and the United Nations through a series of non-partisan programs.
Connie Milstein, is one of four founders of HDI. Milstein is the Principal of Ogden CAP Properties, LLC, a New York Property Management and development company. ?As a highly successful businesswoman, Milstein has her hand in many philanthropic endeavors. She?s involved with medical research, international relations and issues, support of military families, and cultural organizations.?Milstein has won several awards recongizing her achievements in philanthropy.
HDI recently announced the addition of two new members of the Congressional Advisory Board, Congresswoman Marcia Fudge (Democrat-Ohio) and Congresswoman Frederica Wilson (Democrat-Florida). ?The two new members were brought on board to help HDI?s program planning and increase educational opportunities for children around the world.
Congresswoman Fudge serves both the Committee on Agriculture and Committee on Education and the Workforce. Fudge has a dedication to nutrition and has experience developing programs. Fudge also has experience working with public education and voters? rights programs.
Congresswoman Wilson was first elected to the Florida State House of Representatives in 1998. ?Currently, Wilson serves on the Congressional House Committee on Foreign Affairs and the House Committee on Science, Space and Technology. ?Wilson has experience working on bipartisan legislation and has focused on increasing jobs.
The addition of member Fudge and Wilson brings the Congressional Advisory Board up to 29 total members. The growing membership is an exciting opportunity for HDI to expand program initiatives and make a difference.
Source: http://www.goodyearatv.com/hdi-announces-new-congressional-advisory-board-members/
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Monday, July 30, 2012
Insurance premiums may increase to ensure flood-hit homeowners get
UK householders face higher home insurance premiums so that those in high flood risk areas can still get cover.
The Association of British Insurers (ABI) says that the insurance industry and the government are discussing a scheme to ensure that 200,000 households affected by flooding will be able to renew their policies next year.
The scheme, proposed by the ABI, means a cap on premiums. Any house that would normally incur a much higher premium because of flood risk will have the extra paid out of a levy on every home policy in the UK.
Insurers agreed a statement of principles with the government in 2008 to renew cover ? usually at a very high premium and with an even higher excess ? for flood victims. But this agreement runs out on 30 June 2013, and householders then face being refused insurance unless the government and the industry come to a new agreement.
A spokesman for one insurer said that providing cover for people in high-risk areas such as Hebden Bridge, which has flooded three times in as many weeks, was becoming assurance rather than insurance; covering an event that would definitely happen, rather than a risk.
He added: There are policies being written now that will not be offered renewal next year unless the government acts soon.
The ABI said a scheme called Project Noah, which would involve reinsuring flood risk on the international market, had now been discounted.
A government spokesman said: We have not yet arrived at an agreement, but discussions with the insurance industry continue to be constructive and we are working together to reach a solution that is practical and affordable for households. Were mindful of those on lower incomes living with the risk of flooding. Thats why were considering ways to keep flood insurance affordable for those who might struggle most with premium increases.
The ABI estimates that damage caused by the floods in the last few weeks amounts to between ?200m and ?300m.
Source: http://www.txinsurancepro.net/?p=542
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Student in Kent State threat due in court
KENT, Ohio (AP) ? Authorities say a Kent State University student is due in court after allegedly posting a message on Twitter saying he planned to "shoot up" the northeastern Ohio campus.
Nineteen-year-old William Koberna was arrested at his parents' home in the Cleveland suburb of Brunswick Sunday afternoon. The sophomore has been charged with inducing panic, a felony, and aggravated menacing. He was to be arraigned Monday.
A university spokesman says the tweet was posted July 25.
University officials monitoring Twitter last week noticed the profanity-laced message and contacted police. They said it included a threat that "I'm shooting up your school ASAP."
Kent State University President Lester Lefton said in a statement that "our students, employees, and all those who come to campus should know that their safety is our top priority."
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Haryana land transfer: IAS officer hints at ... - Real Estate India
??|?? July 29, 2012 ?? 12:02pm ??|
A senior Haryana IAS officer has hinted at an alleged nexus between politicians and bureaucrats in a case of transferring prime land in Gurgaon ? belonging to gram panchayats and the government ? to individuals and real-estate firms.
Director General of Consolidation Holdings (Haryana) Ashok Khemka, in a letter to the Additional Chief Secretary and Financial Commissioner (Revenue), has recommended the registration of a criminal case against two senior Haryana IAS officers ? S C Goel and Anil Kumar. He also suggested a thorough probe be conducted by the Central Bureau of Investigation (CBI).
In the letter (copy with The Indian Express) dated July 25, Khemka highlights 20 cases in which real-estate firms and private individuals were given prime land in Gurgaon (mainly Sectors 58-63 and Sector 65-67), through orders issued by Anil Kumar and SC Goel. The cases also reveal that consolidation proceedings of the land under question were completed 40 to 45 years ago, but had only now been transferred.
Khemka?s letter reads that the beneficiaries in whose favour land was transferred, ?would not have even been in existence, during the pendency of the consolidation proceedings?.
Calling it a ?gross abuse of position by the authority concerned?, Khemka hinted at the possibility of several other such orders that were passed by other officers.
News Published Under:?? Gurgaon | No Comments ?
Comments
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Sunday, July 29, 2012
MotherJones: The world's super-rich are hiding $21 trillion in offshore tax havens. That's more than GDPs of US & Japan combined. http://t.co/xu595eVG
Sorry, Readability was unable to parse this page for content.
Source: http://twitter.com/MotherJones/statuses/229607372144902144
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House Ways and Means chairman fighting cancer
WASHINGTON (AP) ? The chairman of the House's tax-writing committee says he's been diagnosed with a "very early, highly treatable and curable type" of cancer.
GOP Rep. Dave Camp of Michigan says in a statement that doctors found non-Hodgkin lymphoma during a recent physical. Camp says he'll continue in Congress and retain his committee chairmanship during chemotherapy.
Non-Hodgkin lymphoma is a cancer that begins in the cells of the immune system. The 59-year-old Camp says he has large B-cell lymphoma. B-cells are a type of white blood cell that helps fight infections.
Camp, who's served since 1991, has said he wants to combine a push to head off pending tax increases with ways to force Congress to revamp the tax code next year.
Source: http://news.yahoo.com/house-ways-means-chairman-fighting-cancer-190130973--finance.html
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Summer Wedding Wreath with Ribbon Roses Tutorial
Summer Wedding Wreath with Ribbon Roses Tutorial
When I started this today, the sun was shining and I thought any Bride would be happy with the day... but then the rains came, then the thunder and lightening, and finally, to round it off we had hail. ?The UK will certainly take the weather gold medal this weekend, if only for diversity!One of the things I always remember about wedding is not so much the dress but the little touches, which is why this wreath is made from fabrics you might be making your bride and bridesmaid's dresses from. ?I hit my Jane Means stash of ribbons to start off this week's tutorial, so get yourself ready and let's get started:
You will need:
A polystyrene form
Half a yard / metre each of ?net, organza or sari fabric (basically a sheer weave fine fabric)
Rotary cutter with pinking wheel and cutting mat or pinking shears
Chopstick
2/3 yards or metres of organza wired ribbon?
Household scissors
Matches
Tweezers or small pliers
2 metres of plain ribbon
Well we have made wreathes at Christmas using this technique last year but this is a little bit different as the wreath is a little more blousey.
Start by cutting out three strips, three inches wide, then cut across them at three inches to form three inch squares. I found some fabulous organza with a sparkle diamante type detail.
Using your chop stick in the centre of the square, push it into the polystyrene form.
Continue to build it up, cutting more squares as you need them, you don't need to cover every inch... walk away from the wreath and turn it round as you can become a touch anal about there being no white showing!
When you are happy that it is covered, go an make yourself a drink and take a final look.
Something like this will do :)
Now cut your ribbon, you will need lengths of about 18", use you household / kitchen scissors as you will be cutting through wire and I will personally come to your house and remove all your dressmaking scissors if I catch you blunting them on wired ribbons! ?Remember to flame the ends with your matches to seal them.
You will find fine wire running through the top and the bottom of your ribbon, gently tease the ends out of the top of the ribbon and pull carefully to start gathering the ribbon... do not tug, the wire is fine and will break...
Now from the ungathered side fold over one end, which will tuck it in when you start to roll up your rose. ?Now you could use a match to wind the ribbon around but I find it easier to wind it free hand.
?You can manipulate your flower when you have finished winding.
Twist the two wires together a few times to secure your rose, then separate them.
Place the rose on your wreath, manipulate your wire through the organza and net, to the back of the wreath and use your pliers to twist the wire to hold the rose in place. ?Tidy in the ends and cut away the excess. ?Repeat the process to add as many roses as you wish.
Now use a loop of ribbon to create your bow at the top of the wreath and pop it on the front door to show everyone where the festivities are starting from.
And there you have it, a souvenir of a very special day.
Now let's go look at the Olympian efforts that the crafters have made over at Handmade Monday... I am predicting, items in red, yellow, blue, green and possibly black... what do you reckon?
And for those who are marrying this year... just a touch of schmaltz
Have a great first week of Olympic treats!
Source: http://feedproxy.google.com/~r/RosMadeMe/~3/fLe9aQzRqLs/summer-wedding-wreath-with-ribbon-roses.html
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Saturday, July 28, 2012
Learning DIY With These Home Improvement Ideas That You Can Use
When you start any home improvement task, be certain not to underestimate the time and money requirements involved. Create a list of all the things you need to do. It is also good to get other peoples opinions in case that you missed something. By knowing everything you have to do, you can save tons of money.
Take your time when doing demolition during a home renovation. You need to ensure that your structures are not a support to your home before you rip them out. If you find electrical components, it might cost a lot to repair any issues you have created.
Save money by purchasing a drain snake. You will not need to use drain cleaners as often. Using a drain snake can be difficult the first time. You might need a plumber to show you how before you try yourself. Invest in a snake thats the correct size or you may damage your pipes.
Dont worry about your lack of education when it comes to home improvement. You can make improvements on your home in little time by using the advice in this article. The ideas from this article have given you a number of unique and interesting options for your home. Now get out there and get those improvements done so that you can improve the value of your home!
Learn more about a href=?http://www.surreybasements.co.uk?Tanking/a or a href=?http://www.surreybasements.co.uk?Cavity Drainage/a
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Anaheim Police Shooting: Officers Fire At Suspected Burglars After
ANAHEIM, Calif. -- Anaheim police opened fire on a burglary suspect Friday morning, days after officer-involved shootings killed two people and sparked violent protests in the Southern California city.
It was unclear whether anyone was hurt in the confrontation.
"We have been in contact with the local hospitals. There is no indication that anyone has come in with a gunshot wound," Sgt. Bob Dunn said.
Police answering a burglar alarm at a condominium complex clubhouse at about 3:15 a.m. spotted appliances outside and a man leaving the building, Dunn said.
An officer began chasing him while another officer checked out a nearby car, which suddenly sped off in the direction of the first officer, Dunn said.
The second officer then opened fire on the car but the driver escaped, Dunn said.
A search for the first man ended about 45 minutes later when a paroled burglar was found hiding near some train tracks, Dunn said.
The man had been bitten by a police dog and was taken to a hospital for treatment before being booked on suspicion of burglary and resisting arrest. His name was not immediately released.
The shooting came as activists in Los Angeles, Seattle and other cities called for Friday solidarity protests over the earlier police killings.
Last Saturday, a police officer fatally shot Manuel Diaz outside an apartment complex. Officers said Diaz, who had a criminal record, failed to heed orders and threw something as he fled police.
The city's police union said Diaz reached for his waistband, which led the officer to believe he was drawing a gun.
Diaz's family, which is suing for $50 million in damages, says he was shot in the leg and the back of the head.
On Sunday night, police shot to death Joel Acevedo, a suspected gang member they say fired at officers after a pursuit.
The shootings prompted four days of violent protests, culminating Tuesday night in hundreds of demonstrators surging through downtown streets. Police said some in the crowd smashed the windows of 20 businesses, set trash can fires, threw rocks and bottles at police and damaged City Hall and police headquarters. Two dozen people were arrested.
However, Diaz's mother publicly called for an end to violence, and the streets remained calm over the next few days.
The Orange County district attorney's office is investigating and the U.S. attorney's office and the FBI also agreed to review the shootings to determine if civil rights investigations are warranted.
Friday's shooting will not be investigated by the county district attorney's office unless it turns out someone was injured, Dunn said.
Meanwhile, Police Chief John Welter urged residents to ignore what he termed irresponsible rumors about Diaz's death pending the outcome of the investigation.
Earlier on HuffPost:
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Source: http://www.huffingtonpost.com/2012/07/27/anaheim-police-shooting_n_1710181.html
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amitbd.com ? Non Certified Criminal Lawyers ? Legal ? amitbd.com
A certified Criminal lawyer NYwould be the best lawyer you need in a criminal case. This is a lawyer who would be able to prevent harassment and violation of American constitution on his or her client. An experienced lawyer has lots of connections and contacts that might save a criminal or accused from the jaws of jails. These lawyers are straightforward in their defense and might step on toes in making sure that they win their cases or reduce the sentence of their clients who are accused of crimes or who must have committed crimes.
Examination for Criminal Lawyers
Criminal lawyer NY must pass the New York bar examination before applying for law establishments that are specialized in criminal law practice. There are various laws and bills that have been adopted by New York State government and there are also the federal criminal laws of United States of America that would guide any criminal lawyer in New York. There are two types of legal cases which are the criminal and civil court cases. The civil court is interested in lawsuits involving disagreements, debts, anger and so forth that have nothing to do with crime while in the criminal court, it is the government that files as a prosecutor against a criminal and the punishment is either a fine or jail. This is why you should get a qualified criminal lawyer for your legal case.
Criminal lawyer NY is a legal expert who takes care of people who are in need of legal support and advice because of criminal conduct that they are charged with. There are so many lawyers in New York that are specialized in the defense of people or firms that have problem with the law. These experts are employed to work within a jurisdiction where criminal courts are set up for them. Sometimes, these lawyers are called public defenders that work or operate according to the law of the jurisdiction that they are living and working from. In New York, these public defenders are in charge of taking care of people arrested, criminal charges that might be in the past or present or investigation of criminal activities.
Source: http://amitbd.com/legal/non-certified-criminal-lawyers/
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Friday, July 27, 2012
self improvement - How To Quickly Develop An Attractive Personality
If there's one thing that can help you out in every single aspect of life, it's having an attractive personality. Unlike your looks, which you're pretty much stuck with, you can develop your personality. And most people would readily agree that while looks are important, it's personality that really matters. In this article, you'll learn some proven tips that will help you develop an attractive personality that will make life much, much easier.
The first thing to do is think of somebody to model. This can be a real person you know, a real person you don't know, or even a character from a book or a movie. You can even put together several personality traits from several different people. Just don't get your brain from somebody named "Abby Normal."
One thing that has a dramatic impact on your personality is your voice. If your voice is high and squeaky, like Mickey Mouse, you won't ever be elected president. On the other hand, if you sound like the Dark Knight, you wouldn't make a very good kindergarten teacher. Make sure to model your voice to be congruent with the personality you're trying to create.
It's one thing to wish to change, but it's quite different to actually making the changes. It can feel very uncomfortable changing the way you walk and talk, so it may take some getting used to. But the more you practice these new behaviors, the more quickly they'll become who you are. Just dedicate yourself to making them happen, rather than vaguely wishing they'll happen on their own.
A powerful way to affect immediate change is to alter the way you dress. These make a quick impression on people. It's easy to change your personality when people are treating you differently.
One way to help you change your persona is to engage in different activities. Try different sports, hobbies, or other activities that people with your desired personality would engage in.
Another great way to change your personality is to hang out with different people. Obviously, if you are trying to become known as a intelligent, forward thinking genius, you shouldn't spend time in the sports bar every weekend. Maybe hanging out with the chess club is a better alternative.
You see, it really easy to change your personality. Just figure out the person you want to be, and start doing things they'd do. Talk they way you imagine them talking, and act the way you imagine them acting. You'll be a completely new person in no time.
If you'd like to take advantage of some powerful mind control techniques to powerfully improve your life, then head on over to the self improvement site today. You'll find some powerfully effective tools to help you get whatever you want out of life.
Keywords: self improvement,self development,NLP,hypnosis,persuasion,self help tools,mind control
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Insert Coin: Botiful telepresence robot for Android (video)
In Insert Coin, we look at an exciting new tech project that requires funding before it can hit production. If you'd like to pitch a project, please send us a tip with "Insert Coin" as the subject line.
Remote-controlled cameras are nothing new -- heck, some even ride atop robotic vacuums -- but this Android smartphone-powered device delivers quite a bit of versatility in a petite package with a reasonable price tag to boot. Botiful, a "social telepresence robot," serves as a roving platform for your Android smartphone. You can move the handset (and its front-facing camera) up and down as it speeds along any flat surface, responding to commands from someone on the other end of a Skype video chat. Once you connect the device to your Android phone through Bluetooth or USB, you can control its direction from a pop-up window within Skype, letting you position Botiful however you see fit. If your Android phone doesn't have a front-facing camera, you can flip it around to use the rear shooter -- of course, you won't be able to see the display in this configuration, so it won't be ideal for two-way chats. Naturally, this makes the duo a natural choice for surveillance and baby monitoring, but it can also be used to provide a more immersive experience during conference calls or for sending back video from locations that aren't easily accessible, such as the undercarriage of a car.
Designed in a garage in California (no, really), Botiful is already functional, with working software as well. The current configuration requires Skype for control, though an SDK will allow developers to create other control apps for the device -- and who knows, the seemingly capable inventor could release another tool of her own before it's set to hit production later this year. With much of the design already completed, the project sponsor is turning to Kickstarter to raise the funds necessary to launch Botiful to production -- the device could ship as soon as November if it reaches a $90,000 goal before August 22nd. Available in white, blue or red, the remote-controlled rig is currently only compatible with Android, though iOS support may come if funding exceeds a $100k threshold. There's still more than three weeks to go to make your pledge, with a limited number of pre-order slots available for $199 (retail pricing is expected to come in at $299). Hit up the source link below to show your support.
Continue reading Insert Coin: Botiful telepresence robot for Android (video)
Filed under: Cellphones, Digital Cameras, Robots
Insert Coin: Botiful telepresence robot for Android (video) originally appeared on Engadget on Fri, 27 Jul 2012 14:18:00 EDT. Please see our terms for use of feeds.
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A blue debut
L.A.'s new addition goes 2-for-4 with an RBI in a 3-2 loss in 12 innings
APHanley Ramirez acknowledges first-base coach Davey Lopez after driving in a run with a single in the sixth inning against the Cardinals on Wednesday night.
Associated Press Sports
updated 2:32 a.m. ET July 26, 2012
ST. LOUIS - Hanley Ramirez gave the Los Angeles Dodgers a good look at what he can bring to the table Wednesday night.
Ramirez, traded from Miami earlier in the day, went 2 for 4 with a walk, an RBI and a run scored in his debut, but it wasn't enough to lift the Dodgers in a 3-2, 12-inning loss to the St. Louis Cardinals.
Still, Ramirez felt good about his first game with a new team.
"I feel comfortable," Ramirez said. "Great group of guys here; you just go out there and have fun. I'm happy to be here."
Hoping for a smooth transition, Ramirez started at third base. After moving from shortstop when the Marlins signed Jose Reyes, Dodgers manager Don Mattingly said Ramirez will return to his old position as soon as he's comfortable with a switch.
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Ramirez took to wearing the Dodger blue right away, hitting a triple off the center-field wall in his first at-bat.
"I thought it was a pop-up to center to be honest," Ramirez said. "It just kept going and going."
Los Angeles acquired the three-time All-Star and former NL batting champion along with reliever Randy Choate, while the Marlins received pitcher Nathan Eovaldi and minor league pitcher Scott McGough.
Choate pitched a scoreless inning in relief in his debut.
"The extra innings get you in the game," Choate said. "It's just been kind of a long day."
Mattingly's day ended a little early when he was ejected in the 10th inning by home plate umpire Jeff Kellogg for arguing balls and strikes. Mattingly was still upset afterward.
"Nothing really happened," he said. "I was just getting frustrated. The strike zone was horrible."
The 28-year-old Ramirez said before the game he didn't care where he played, emphasizing how happy he is to join a contender. He declined to blame his off-year offensively on the position switch and agreed with suggestions that this was a fresh start.
He was batting .246 with 14 homers and 48 RBIs in 93 games coming in.
"Yeah, why not? It's a new beginning," Ramirez said. "I've just got to go out there and have fun."Ramirez's new teammates sensed the commitment from ownership to keep charging. The Dodgers have won five of seven and are 2 1/2 games behind NL West-leading San Francisco.
"Yeah, it's no excuses now," lefty ace Clayton Kershaw said. "Last year we had excuse, excuse, excuse and we ended up playing pretty well in the second half, and this year it's pretty much all on us."
Mattingly has been using a combination of Juan Uribe, Adam Kennedy and Jerry Hairston Jr. at third base, and career minor leaguer Luis Cruz has been starting at shortstop in place of injured Dee Gordon.
"It works best for us right now at short," Mattingly said. "The best answer I got from Hanley was, `It doesn't matter. Third or short, I just want to win."'
Mattingly added that he'd be patient with Ramirez.
"It's really just up to him as far as I'm concerned, it's not something I'm going to see that he's ready," the manager said. "It's going to be more like he tells me he's ready, I'm playing short."
After getting announced to zero response from a near-sellout crowd for his first at-bat in the second, Ramirez tripled against Kyle Lohse and scored on a sacrifice fly by James Loney to give the Dodgers an early lead.
Ramirez's bat gives Mattingly a big three to anchor the lineup along with Matt Kemp and Andre Ethier. Kemp found out about the trade sitting in bed checking Twitter.
"I was like `Whoa, that can't be true,"' Kemp said. "And then I saw more tweets and more and I was like `Wow, I guess this is true."'
Prior to the trade, the Dodgers were in the bottom half of the National League in most offensive categories.
Mattingly advised Ramirez to take a deep breath and just be himself. He said he wouldn't worry about whatever happened in the past
"I'm sure he's going to want to show people he can play," Mattingly said. "But we'll be mindful of just reminding him that we just want him to play.
"Have good at-bats, play the game, and do his thing. That's all we'll ask."
Notes: David Freese had two hits for St. Louis. He is batting .565 (13 for 23) during an eight-game hitting streak. ... Dodgers starter Chris Capuano (10-5) can match his win total for 2011 with a victory Thursday. He'll have to reverse some history - he is winless in five career games at Busch Stadium (0-3, 7.04 ERA). ... Lohse's quality start was the 20th in a row for the Cardinals.
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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More newsA blue debut
Hanley Ramirez?went 2-for-4 with an RBI in his Dodgers debut, but the Cardinals won 3-2 in 12 innings on Wednesday night.
Source: http://nbcsports.msnbc.com/id/48330253/ns/sports-baseball/
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Thursday, July 26, 2012
Currency Forward Contract is Liability to Agreement Holders to Buy ...
Finance | Personal Finance | * Written by Cory Pinnock | Wednesday, 25 July 2012 01:40 | Word Count: 727
A large number of Foreign exchange investors opt for currency forward contract to hedge their investments. Contract holder is actually required to purchase or sell foreign currencies at pre-specified price, quantity as well as day in this hedging technique. These contracts can't be shifted by the contract owner. The details talked about in the agreement have to be put into practice thoroughly. The main benefit of currency forward contract is actually that it shields your account against movements as well as you have clear thought regarding just what particular account will you obtain when the agreement ends.
It is pretty important for buyers of the modern-day to master strategies concerning post trade risk management. Your capital is at threat the minute you jump into unstable market of foreign currency trading. There are numerous sorts of hazards including credit risk, operational risk, legal risk and also others coming your path when you are trading foreign currency. To start with, the buyers should distinguish whether the risk is escalating or lessening. Product intricacy, product variety and constantly increasing quantities are the signs of increasing chance. Likewise, minimizing danger additionally has its private impressive characteristics such as functional convergence and utilities consolidation. The buyer needs to review the currency market closely to ensure that? he can understand whether the possibility is increasing or minimizing as well as prepare his strategy consequently.
Another handy hedging technique is forex trading options. Currency options supply the buyers authority and not the obligation to sell or buy currency at the set stretch of time and exchange rates. Currency options offer the holder right where as in currency forward contract, the contract holder is obliged. In order to get his investments hedged, buyer has got to shell out a token payment to the agent as per the quantity of agreements. As soon as you hold currency options, you have authority to demand predicted sum even if the industry is going through a bearish stage.
You will discover varieties of foreign currency options. You have to pick what suits you the best. For examples, it is possible to encash European option simply when it ends. Investor is provided a lot more flexibility when he chooses American option since they are able to encash it every time they want before termination. Bermudan option is actually a distinctive type of option which lets buyer to employ it on predetermined dates just before expiration solely. A huge class of options possessing elaborate fiscal structure can be put into class of exotic options. Any different option than exotic options is actually named as vanilla option. Foreign currency options are available in wide variety in the industry. Investor needs to decide which will make him maximum rewards.
These days there are a huge number of web sites that will assist investors to take smarter decision relating to foreign currency trading. You can select the internet site that offers the most effective commercial foreign currency services. Ahead of deciding on the web-site, make certain that it keeps secrecy concerning your steps and also currency exposure. Additionally you have to make certain on the name of commission your profit margin isn't swallowed up by the internet site. In order to avoid all chances of scam, you should carefully check the plan provided by the web site. Foreign currency trading is absolutely no more a risk together with a huge number of currency hedging options. Buyer should decide his comfort zone and then pick the strategy keeping that in mind. Are you prepared to start the trip on the way to thriving accomplishment in the foreign exchange market?
Cory Pinnock is basically a forex investor doing the job together with a top forex consultancy corporation. He has substantial experience in the niche plus is actually acknowledged for his keen sense of intelligent investment. His online posts on this subject are put into practice by a wide readership.
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6 Dangerous Reasons People Do Not Set Goals and Never ...
Goal-setting is the framework for personal achievement. It is the backbone of becoming a person you desire to be. Setting and achieving personal goals will guarantee you success. Most people who do set goals have little to no understanding of goal-setting and as a result fail to achieve them and never succeed. You would think that if goal-setting was the ultimate skill and secret to success that everyone would develop their own personal goals and learn to achieve them. Unfortunately, the world is not that perfect. There are six dangerous reasons people do not set and achieve their goals which act like a road block to their success.
The first reason I believe why people do not set goals is they do not see its importance. Like people who do not develop their communication and other aspects of themselves, they do not see the importance of setting goals. I have met people who are unbelievably resistant to developing their communication. They have actually found it insulting to think they need to improve how they communicate! Every single person on the face of this Earth can always communicate more effectively and have their life improve as a result. Likewise, with goals there are people who do not see the importance of setting personal goals. Goal-setting forms the foundations for personal achievement and it is of the utmost importance.
The second reason why people do not set goals is a fear of others caused from criticism. People criticize because they see faults in others or are brainwashed by society and other beliefs into thinking greatness cannot be achieved. They criticize to hold people back from achieving goals. Average people do not want others to go beyond average. A person can fear setting goals because each time they have set goals in the past, others have criticized and shot down their dreams. Others impose their own self-limiting beliefs through criticism instilling fear within the person. To bluntly solve this, screw what people think. Screw allowing people to destroy your life with their beliefs. Society is filled with endless garbage to prevent you from achieving your goals. If you want something, go and get it by setting and achieving personal goals.
The third reason why people do not set goals is a fear of failure. They can think success is derived from not failing. The opposite is true. Success comes from failing a lot and failing fast. Famous inventor Thomas Edison said, ?I haven?t failed. I?ve just found 10,000 ways that won?t work.? Being an inventor, Edison understood that failure was apart of success. Failure was the nuts and bolts that constructed his success. Understand that failure occurs and it shows you are taking action. Learn from failure and enjoy knowing you are moving towards your goals instead of fearing to set out after them in the first place.
The fourth reason why people do not set goals is a fear success. People who fear success believe it is bad. The fear is common in wealth and wanting an attractive partner because negative results will occur. They believe wealth is evil or a certain type of partner is unfaithful. The fear prevents them achieving what they want by not laying the foundations of their desire with goal-setting.
The fifth reason why people do not set goals is they do not know how. This reason relates to fear of failure where the person has set goals in the past, but has not achieved them and becomes discouraged from the failure. These people become disheartened from the failure and think failure is imminent. They do not learn from past mistakes and move towards personal growth. There are techniques such as setting SMART achievable goals which I have written about but are not covered in this article. Using SMART goals enables you to set and achieve goals then merely wishing a result based on temporary motivation too common around the new years period.
The sixth reason why people do not set goals is they lack the inner desire to want something greater than what they currently have. For them, the ordinary or even sub-ordinary is sufficient. These people do not believe they can reach or deserve success because society has conditioned them into thinking they are ordinary people and therefore must do ordinary things. It can also be caused by failure, criticism, and other reasons as to why people do not set goals.
Did you find yourself relating to one of these six dangerous reasons people do not set goals and as a result never succeed? Do not fret too much because you are now more self-aware and able to doing something about. All that is required for you to do is learn how to set achievable goals. I personally advise people how to set SMART, achievable goals technique because its congruency with successful goal-setting is spot on. You set specific, measurable, attainable, realistic, and tangible goals leading to your success. Master this skill and you will have the most powerful personal development technique in your grasp to achieve success.
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Herrera scores twice to help Montpellier beat KC
Associated Press Sports
updated 11:13 p.m. ET July 24, 2012
KANSAS CITY, Kan. (AP) - Emanuel Herrera scored twice in the second half to lead defending French champion Montpellier to a 3-0 victory over Sporting Kansas City in an exhibition match on Tuesday night.
Gaetan Charbonnier also scored for Montpellier, which held Sporting without a shot on goal and snapped the home side's three-match unbeaten streak in international exhibitions.
Herrera, who moved to Montpellier in the offseason after scoring 38 goals over his last two seasons in Chile, scored in the 72nd minute off an assist from Anthony Mounier to put Montpellier up 2-0. He added another goal in stoppage time, tracking down goalkeeper Eric Kronberg's deflection of Remy Cabella's shot and putting it back into the net.
Charbonnier scored in the 39th minute to put Montpellier up 1-0, heading home a high pass from Marco Estrada.
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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PST: Soccer star in England Tuesday, in Philadelphia for MLS All-Star game on Wednesday, then back to London for the Olympics' Opening Ceremony on Friday.
Source: http://nbcsports.msnbc.com/id/48311964/ns/sports-soccer/
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Microchip Giant ARM Reports Q2 Earnings: Sales ?136M, Net Profit ?39.4M, EPS Of ?3.58; ?Record Order Backlog?
ARM Holdings -- supplier of microchips for Apple's iPhone and iPad products, Samsung's Galaxy line and soon technology for Microsoft's Windows 8 devices -- continues to report strong results while riding the wireless device boom and expanding to newer areas. The company reported Q2 earnings (ended June 30) of ?135.5 million ($213 million), beating analyst estimates of $206 million. Net profit was up by 48 percent, to ?39.4 million compared to ?26.6 million for the same quarter a year ago. Pointedly, the company is gearing up for continuing good fortune, at least for the next quarter: It says it has a "record order backlog" that will let it ride well into Q3, but cautioned that macroeconomic uncertainties may impact what happens in Q4.Source: http://feedproxy.google.com/~r/Techcrunch/~3/K8Y-WxpfL3o/
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Swiss Study: Colonoscopy with Polypectomy Reduces Cancer
OAK BROOK, Ill.?A study from researchers in Switzerland found that colonoscopy with polypectomy significantly reduces colorectal cancer incidence and colorectal cancer-related death in the general population.
A total of 12 colorectal cancer cases were identified in the screening group of 1,912 patients and 213 cases of colorectal cancer were found in the non-screened group of 20,774 patients. One of the 12 persons of the screened individuals with a colorectal cancer and 51 of the 213 persons of the non-screened individuals with a colorectal cancer died because of their cancers. The study appears in the July issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).
Colorectal cancer (CRC) has a very high incidence in Switzerland as well as in other European countries and is the second most frequent cause of cancer-related deaths in Europe. It is detected in approximately 413,000 people in Europe every year, half of whom die because of the disease. Therefore a need exists for efficient strategies for prevention and early detection of CRC. Colonoscopy with the possibility of an immediate polypectomy is a recommended and preferred screening method because polyps (growths in the colon) can turn into cancer over the course of years to decades. Removing polyps during a colonoscopy prevents that polyp from becoming cancerous.
?In contrast to earlier CRC screening studies that used colonoscopy, this population-based closed cohort observational study aimed to obtain complete and comparable data on CRC incidence and CRC-related mortality after a single screening colonoscopy compared with no screening, while taking into account the potential differences in risk profiles between the screened and non-screened participants," said study lead author Urs A. Marbet, Cantonal Hospital of Uri, Altdorf, Switzerland. ?We found that colorectal cancer screening by colonoscopy markedly reduces not only the incidence of colorectal cancer, but also cancer-related death. We are unaware of any other long-term prospective study assessing the role of colonoscopy screening for the reduction of colorectal cancer incidence and mortality in a well-defined, population-based setting under real-life conditions."
Source: http://www.endonurse.com/news/2012/07/swiss-study-colonoscopy-with-polypectomy-reduces.aspx
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HTC to build another Facebook phone in 2013, says Bloomberg
Despite failing to set the world alight with 2011's ChaCha and Salsa, HTC and Facebook will collaborate once again to bring another Facebook phone to market next year, according to reports from Bloomberg. ?Details on the purported device are scant at the moment, but the report, which cites the usual "people with knowledge of the matter," indicates a mid-2013 release, after the launch was apparently pushed back from the end of 2012.
The site doesn't mention Android specifically, but we'd be surprised if Google's OS wasn't involved in some way or other, given the history of collaborations between Facebook and HTC. Bloomberg? says the phone will run a "modified" operating system, which suggests to us that we may see a forked version of Android, similar to what Amazon's done with the Kindle Fire. For the less technically inclined, that means a version of the OS built upon the open-source code, and most likely excluding any Google apps.
Android followers will remember that last year's HTC ChaCha (aka AT&T HTC Status) and its Europe-only sibling, the Salsa, weren't met with much success. So it's possible we'll see the two companies adopt a different strategy this time around. With Facebook getting more involved in the app space, it'd make sense for the Facebook phone to be heavily invested in this, rather than something like Google Play.
In any case, it seems the rumored device is still the best part of a year away from completion, so it's possible we'll see more changes throughout the course of development.
Source: Bloomberg
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Source: http://feedproxy.google.com/~r/androidcentral/~3/ds6lT0n7ooo/story01.htm
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